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“Our target is to know female reproductive ageing, and why fertility quickly declines starting within the mid-30s,” states Satoshi Namekawa, a professor of Microbiology and Molecular Genetics, in whose lab Munakata operates.
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Utilizing the GCRLE grant, Munakata and Namekawa will appear far more intently at how oocytes are genomically primed and stored for later use. They'll investigate the part of a chromatin remodeler in oocyte survival and fertility.
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GCs are only 1 of numerous differing kinds of contractors, However they provide a crucial position in ensuring a task receives finished and everybody linked to the construction procedure will get compensated.
“We don’t understand how these cells are taken care of for decades,” claims Namekawa. “We want to know The key of the mechanism.
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In 2022, they identified that a list of proteins called Polycomb repressive intricate one (PRC1) helps silence countless genes across the time of start by modifying the composition of spools.
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